EGFR-Mediated Carcinoma Cell Metastasis Mediated by Integrin αvβ5 Depends on Activation of c-Src and Cleavage of MUC1

Receptor tyrosine kinases and integrins play an essential role in tumor cell invasion and metastasis. We previously showed that EGF and other growth factors induce human carcinoma cell invasion and metastasis mediated by integrin αvβ5 that is prevented by Src blockade [1]. MUC1, a transmembrane glyc...

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Detalhes bibliográficos
Main Authors: Lau, Steven K. M., Shields, David J., Murphy, Eric A., Desgrosellier, Jay S., Anand, Sudarshan, Huang, Miller, Kato, Shumei, Lim, Ssang-Taek, Weis, Sara M., Stupack, Dwayne G., Schlaepfer, David D., Cheresh, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346745/
https://ncbi.nlm.nih.gov/pubmed/22586492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036753
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