First Pharmacokinetic and Safety Study in Humans of the Novel Lipid Antiviral Conjugate CMX001, a Broad-Spectrum Oral Drug Active against Double-Stranded DNA Viruses

CMX001 is a novel, broad-spectrum lipid antiviral conjugate (LAC) that produces high intracellular levels of the active antiviral agent cidofovir diphosphate (CDV-PP). Study CMX001-102 was a randomized, double-blind, placebo-controlled, parallel group, dose-escalating study in healthy volunteers. Th...

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Detalhes bibliográficos
Main Authors: Painter, Wendy, Robertson, Alice, Trost, Lawrence C., Godkin, Susan, Lampert, Bernhard, Painter, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346600/
https://ncbi.nlm.nih.gov/pubmed/22391537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05983-11
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