Efficacy of CMX001 as a Prophylactic and Presymptomatic Antiviral Agent in New Zealand White Rabbits Infected with Rabbitpox Virus, a Model for Orthopoxvirus Infections of Humans

CMX001, a lipophilic nucleotide analog formed by covalently linking 3-(hexdecyloxy)propan-1-ol to cidofovir (CDV), is being developed as a treatment for smallpox. CMX001 has dramatically increased potency versus CDV against all dsDNA viruses and, in contrast to CDV, is orally available and has shown...

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Autors principals: Rice, Amanda D., Adams, Mathew M., Lampert, Bernhard, Foster, Scott, Lanier, Randall, Robertson, Alice, Painter, George, Moyer, Richard W.
Format: Artigo
Idioma:Inglês
Publicat: Molecular Diversity Preservation International (MDPI) 2011
Matèries:
Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045966/
https://ncbi.nlm.nih.gov/pubmed/21369346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v3020063
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