Extensive Methylation of Promoter Sequences Silences Lentiviral Transgene Expression During Stem Cell Differentiation In Vivo

Lentiviral vectors (LV) are widely used to stably transfer genes into target cells investigating or treating gene functions. In addition, gene transfer into early murine embryos may be improved to efficiently generate transgenic mice. We applied lentiviral gene transfer to generate a mouse model tra...

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Bibliografische gegevens
Hoofdauteurs: Herbst, Friederike, Ball, Claudia R, Tuorto, Francesca, Nowrouzi, Ali, Wang, Wei, Zavidij, Oksana, Dieter, Sebastian M, Fessler, Sylvia, van der Hoeven, Franciscus, Kloz, Ulrich, Lyko, Frank, Schmidt, Manfred, von Kalle, Christof, Glimm, Hanno
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2012
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345972/
https://ncbi.nlm.nih.gov/pubmed/22434137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.46
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