Extensive Methylation of Promoter Sequences Silences Lentiviral Transgene Expression During Stem Cell Differentiation In Vivo

Lentiviral vectors (LV) are widely used to stably transfer genes into target cells investigating or treating gene functions. In addition, gene transfer into early murine embryos may be improved to efficiently generate transgenic mice. We applied lentiviral gene transfer to generate a mouse model tra...

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Detalhes bibliográficos
Main Authors: Herbst, Friederike, Ball, Claudia R, Tuorto, Francesca, Nowrouzi, Ali, Wang, Wei, Zavidij, Oksana, Dieter, Sebastian M, Fessler, Sylvia, van der Hoeven, Franciscus, Kloz, Ulrich, Lyko, Frank, Schmidt, Manfred, von Kalle, Christof, Glimm, Hanno
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345972/
https://ncbi.nlm.nih.gov/pubmed/22434137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.46
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