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Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression

Efficient in vivo selection increases survival of gene-corrected hematopoietic stem cells (HSCs) and protects hematopoiesis, even if initial gene transfer efficiency is low. Moreover, selection of a limited number of transduced HSCs lowers the number of cell clones at risk of gene activation by inse...

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Autors principals: Ball, Claudia R., Pilz, Ingo H., Schmidt, Manfred, Fessler, Sylvia, Williams, David A., von Kalle, Christof, Glimm, Hanno
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976372/
https://ncbi.nlm.nih.gov/pubmed/17496202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-11-053710
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