High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies

Gene transfer to hematopoietic stem cells with integrating vectors not only allows sustained correction of monogenic diseases but also tracking of individual clones in vivo. Quantitative real-time PCR (qPCR) has been shown to be an accurate method to quantify individual stem cell clones, yet due to...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Giordano, Frank A, Appelt, Jens-Uwe, Link, Barbara, Gerdes, Sebastian, Lehrer, Christina, Scholz, Simone, Paruzynski, Anna, Roeder, Ingo, Wenz, Frederik, Glimm, Hanno, von Kalle, Christof, Grez, Manuel, Schmidt, Manfred, Laufs, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449016/
https://ncbi.nlm.nih.gov/pubmed/26052530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.61
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