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Abnormal Termination of Ca(2+) Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

RATIONALE: Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have been associated with both cardiac arrhythmias and cardiomyopathies. It is clear that delayed afterdepolarization resulting from abnormal activation of sarcoplasmic reticulum Ca(2+) release is the primary cause of...

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Detalhes bibliográficos
Main Authors: Tang, Yijun, Tian, Xixi, Wang, Ruiwu, Fill, Michael, Chen, S.R. Wayne
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345272/
https://ncbi.nlm.nih.gov/pubmed/22374134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.256560
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