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Abnormal Termination of Ca(2+) Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies
RATIONALE: Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have been associated with both cardiac arrhythmias and cardiomyopathies. It is clear that delayed afterdepolarization resulting from abnormal activation of sarcoplasmic reticulum Ca(2+) release is the primary cause of...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3345272/ https://ncbi.nlm.nih.gov/pubmed/22374134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.256560 |
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