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Helix stabilization precedes aqueous and bilayer catalyzed fiber formation in islet amyloid polypeptide
Islet amyloid polypeptide (IAPP) is an unstructured polypeptide hormone that is cosecreted with insulin. In patients with type 2 diabetes, IAPP undergoes a transition from its natively disordered state to a highly ordered, all β-strand amyloid fiber. Although predominantly disordered, IAPP transient...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3343364/ https://ncbi.nlm.nih.gov/pubmed/19647750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.07.077 |
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