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Helix stabilization precedes aqueous and bilayer catalyzed fiber formation in islet amyloid polypeptide

Islet amyloid polypeptide (IAPP) is an unstructured polypeptide hormone that is cosecreted with insulin. In patients with type 2 diabetes, IAPP undergoes a transition from its natively disordered state to a highly ordered, all β-strand amyloid fiber. Although predominantly disordered, IAPP transient...

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Bibliografische gegevens
Hoofdauteurs: Williamson, Jessica A., Loria, J. Patrick, Miranker, Andrew D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343364/
https://ncbi.nlm.nih.gov/pubmed/19647750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.07.077
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