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Direct detection of transient α-helical states in islet amyloid polypeptide

The protein islet amyloid polypeptide (IAPP) is a glucose metabolism associated hormone cosecreted with insulin by the β-cells of the pancreas. In humans with type 2 diabetes, IAPP deposits as amyloid fibers. The assembly intermediates of this process are associated with β-cell death. Here, we exami...

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Detalhes bibliográficos
Main Authors: Williamson, Jessica A., Miranker, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222845/
https://ncbi.nlm.nih.gov/pubmed/17123962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062486907
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