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Direct detection of transient α-helical states in islet amyloid polypeptide
The protein islet amyloid polypeptide (IAPP) is a glucose metabolism associated hormone cosecreted with insulin by the β-cells of the pancreas. In humans with type 2 diabetes, IAPP deposits as amyloid fibers. The assembly intermediates of this process are associated with β-cell death. Here, we exami...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2222845/ https://ncbi.nlm.nih.gov/pubmed/17123962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062486907 |
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