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Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin

Islet amyloid polypeptide (IAPP, also known as amylin) is the major protein component of pancreatic amyloid fibers in type II diabetes and is normally cosecreted with insulin from the β-cells of the pancreas. IAPP forms amyloid fibrils rapidly at concentrations well below those found in vivo, yet pr...

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Detalhes bibliográficos
Main Authors: Knight, Jefferson D., Williamson, Jessica A., Miranker, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2548354/
https://ncbi.nlm.nih.gov/pubmed/18765820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.036350.108
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