The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide

Islet amyloid polypeptide (IAPP) is a proposed cause of the decreased beta-cell mass in patients with type-II diabetes. The molecular composition of the cell-membrane is important for regulating IAPP cytotoxicity and aggregation. Cholesterol is present at high concentrations in the pancreatic beta-c...

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Udgivet i:Front Mol Biosci
Main Authors: Christensen, Mikkel, Berglund, Nils A., Schiøtt, Birgit
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Molecular Biosciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100463/
https://ncbi.nlm.nih.gov/pubmed/33968989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.657946
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