Influenza Polymerase Activity Correlates with the Strength of Interaction between Nucleoprotein and PB2 through the Host-Specific Residue K/E627

The ribonucleoprotein (RNP) complex is the essential transcription-replication machinery of the influenza virus. It is composed of the trimeric polymerase (PA, PB1 and PB2), nucleoprotein (NP) and RNA. Elucidating the molecular mechanisms of RNP assembly is central to our understanding of the contro...

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Bibliographic Details
Main Authors: Ng, Andy Ka-Leung, Chan, Wai-Hon, Choi, Sze-Ting, Lam, Mandy Ka-Han, Lau, Kwok-Fai, Chan, Paul Kay-Sheung, Au, Shannon Wing-Ngor, Fodor, Ervin, Shaw, Pang-Chui
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343083/
https://ncbi.nlm.nih.gov/pubmed/22570712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036415
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