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Unpairing and gating substrate duplex ends enforces FEN superfamily specificity
Structure-specific 5′-nucleases, exemplified by the flap endonucleases (FENs), are a superfamily of evolutionarily conserved phosphodiesterases that catalyze the precise incision of a diverse range of DNA and RNA substrates. Superfamily members, that include FENs, EXO1, XPG, GEN1 and the XRNs, play...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341984/ https://ncbi.nlm.nih.gov/pubmed/22118811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2011.10.003 |
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