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Double strand binding – single strand incision mechanism for human flap endonuclease: implications for the superfamily

Detailed structural, mutational, and biochemical analyses of human FEN1/DNA complexes have revealed the mechanism for recognition of 5′ flaps formed during lagging strand replication and DNA repair. FEN1 processes 5′ flaps through a previously unknown, but structurally elegant double-stranded (ds) r...

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Detalhes bibliográficos
Main Authors: Tsutakawa, Susan E., Tainer, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345168/
https://ncbi.nlm.nih.gov/pubmed/22244820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2011.11.009
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