Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

Human flap endonuclease 1 (FEN1) and related structure-specific 5’nucleases precisely identify and incise aberrant DNA structures during replication, repair and recombination to avoid genomic instability. Yet, it is unclear how the 5’nuclease mechanisms of DNA distortion and protein ordering robustl...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Rashid, Fahad, Harris, Paul D, Zaher, Manal S, Sobhy, Mohamed A, Joudeh, Luay I, Yan, Chunli, Piwonski, Hubert, Tsutakawa, Susan E, Ivanov, Ivaylo, Tainer, John A, Habuchi, Satoshi, Hamdan, Samir M
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358979/
https://ncbi.nlm.nih.gov/pubmed/28230529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21884
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