Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

Human flap endonuclease 1 (FEN1) and related structure-specific 5’nucleases precisely identify and incise aberrant DNA structures during replication, repair and recombination to avoid genomic instability. Yet, it is unclear how the 5’nuclease mechanisms of DNA distortion and protein ordering robustl...

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Vydáno v:eLife
Hlavní autoři: Rashid, Fahad, Harris, Paul D, Zaher, Manal S, Sobhy, Mohamed A, Joudeh, Luay I, Yan, Chunli, Piwonski, Hubert, Tsutakawa, Susan E, Ivanov, Ivaylo, Tainer, John A, Habuchi, Satoshi, Hamdan, Samir M
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Biochemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358979/
https://ncbi.nlm.nih.gov/pubmed/28230529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21884
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