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B7/CD28 in Central Tolerance: Costimulation Promotes Maturation of Regulatory T Cell Precursors and Prevents Their Clonal Deletion
According to the “two-step model,” the intrathymic generation of CD4(+) regulatory T (T(reg)) cells segregates into a first, T cell receptor (TCR)-driven phase and a second, cytokine-dependent phase. The initial TCR stimulus gives rise to a CD25(+)Foxp3(−) developmental intermediate. These precursor...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Frontiers Research Foundation
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341949/ https://ncbi.nlm.nih.gov/pubmed/22566820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2011.00030 |
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