B7/CD28 in Central Tolerance: Costimulation Promotes Maturation of Regulatory T Cell Precursors and Prevents Their Clonal Deletion

According to the “two-step model,” the intrathymic generation of CD4(+) regulatory T (T(reg)) cells segregates into a first, T cell receptor (TCR)-driven phase and a second, cytokine-dependent phase. The initial TCR stimulus gives rise to a CD25(+)Foxp3(−) developmental intermediate. These precursor...

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Bibliographische Detailangaben
Hauptverfasser: Hinterberger, Maria, Wirnsberger, Gerald, Klein, Ludger
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Research Foundation 2011
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341949/
https://ncbi.nlm.nih.gov/pubmed/22566820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2011.00030
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