IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening

CDP-ME kinase (IspE) contributes to the non-mevalonate or deoxy-xylulose phosphate (DOXP) pathway for isoprenoid precursor biosynthesis found in many species of bacteria and apicomplexan parasites. IspE has been shown to be essential by genetic methods and since it is absent from humans it constitut...

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Autores principales: Tidten-Luksch, Naomi, Grimaldi, Raffaella, Torrie, Leah S., Frearson, Julie A., Hunter, William N., Brenk, Ruth
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340893/
https://ncbi.nlm.nih.gov/pubmed/22563402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035792
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