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IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening
CDP-ME kinase (IspE) contributes to the non-mevalonate or deoxy-xylulose phosphate (DOXP) pathway for isoprenoid precursor biosynthesis found in many species of bacteria and apicomplexan parasites. IspE has been shown to be essential by genetic methods and since it is absent from humans it constitut...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340893/ https://ncbi.nlm.nih.gov/pubmed/22563402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035792 |
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