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An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2

The non-receptor tyrosine kinase proline-rich tyrosine kinase 2 (Pyk2) is a critical mediator of signaling from cell surface growth factor and adhesion receptors to cell migration, proliferation, and survival. Emerging evidence indicates that signaling by Pyk2 regulates hematopoietic cell response,...

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Bibliografische gegevens
Gepubliceerd in:Drug Des Devel Ther
Hoofdauteurs: Meirson, Tomer, Samson, Abraham O, Gil-Henn, Hava
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Dove Medical Press 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441678/
https://ncbi.nlm.nih.gov/pubmed/28572720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S136150
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