A cardiac microRNA governs systemic energy homeostasis by regulation of MED13

Obesity, type 2 diabetes and heart failure are associated with aberrant cardiac metabolism. We show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroid hormone and other nuclear hormone receptors. MED13, in turn,...

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Main Authors: Grueter, Chad E., van Rooij, Eva, Johnson, Brett A., DeLeon, Susan M., Sutherland, Lillian B., Qi, Xiaoxia, Gautron, Laurent, Elmquist, Joel K., Bassel-Duby, Rhonda, Olson, Eric N.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340581/
https://ncbi.nlm.nih.gov/pubmed/22541436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.029
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