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Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation
Perlecan (Hspg2) is a heparan sulfate proteoglycan expressed in basement membranes and cartilage. Perlecan deficiency (Hspg2(−/−)) in mice and humans causes lethal chondrodysplasia, which indicates that perlecan is essential for cartilage development. However, the function of perlecan in endochondra...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340529/ https://ncbi.nlm.nih.gov/pubmed/22421594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2012.02.006 |
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