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Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition

Perlecan is a component of the basement membrane that surrounds skeletal muscle. The aim of the present study is to identify the role of perlecan in skeletal muscle hypertrophy and myostatin signaling, with and without mechanical stress, using a mouse model (Hspg2(−/−)-Tg) deficient in skeletal musc...

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Detalhes bibliográficos
Main Authors: Xu, Zhuo, Ichikawa, Naoki, Kosaki, Keisuke, Yamada, Yoshihiko, Sasaki, Takako, Sakai, Lynn Y., Kurosawa, Hisashi, Hattori, Nobutaka, Arikawa-Hirasawa, Eri
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939214/
https://ncbi.nlm.nih.gov/pubmed/20541011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2010.06.001
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