Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth

Laminin-1, an extracellular matrix molecule, promotes neurite outgrowth through the interaction of integrin and actin. Monosialoganglioside GM1 in the lipid rafts associates with and activates the NGF receptor TrkA, and enhances neurite outgrowth. However, the role of GM1 in laminin-1-induced neurit...

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Bibliografiske detaljer
Main Authors: Ichikawa, Naoki, Iwabuchi, Kazuhisa, Kurihara, Hidetake, Ishii, Kumiko, Kobayashi, Toshihide, Sasaki, Takako, Hattori, Nobutaka, Mizuno, Yoshikuni, Hozumi, Kentaro, Yamada, Yoshihiko, Arikawa-Hirasawa, Eri
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714420/
https://ncbi.nlm.nih.gov/pubmed/19118221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.030338
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