Synovial perlecan is required for osteophyte formation in knee osteoarthritis

The osteophyte associated with osteoarthritis (OA) is a bony outgrowth formed at the margins of the affected joint through endochondral ossification-like processes. However, the mechanism of osteophyte formation and its pathogenesis are unclear. Perlecan (Hspg2), a heparan sulfate proteoglycan, is e...

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Hlavní autoři: Kaneko, Haruka, Ishijima, Muneaki, Futami, Ippei, Tomikawa-Ichikawa, Naoki, Kosaki, Keisuke, Sadatsuki, Ryo, Yamada, Yoshihiko, Kurosawa, Hisashi, Kaneko, Kazuo, Arikawa-Hirasawa, Eri
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843243/
https://ncbi.nlm.nih.gov/pubmed/23339896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2013.01.004
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