Design and Receptor Interactions of Obligate Dimeric Mutant of Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

Chemokine-receptor interactions regulate leukocyte trafficking during inflammation. CC chemokines exist in equilibrium between monomeric and dimeric forms. Although the monomers can activate chemokine receptors, dimerization is required for leukocyte recruitment in vivo, and it remains controversial...

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Bibliografische gegevens
Hoofdauteurs: Tan, Joshua H. Y., Canals, Meritxell, Ludeman, Justin P., Wedderburn, Jamie, Boston, Christopher, Butler, Stephen J., Carrick, Ann Marie, Parody, Todd R., Taleski, Deni, Christopoulos, Arthur, Payne, Richard J., Stone, Martin J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2012
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340267/
https://ncbi.nlm.nih.gov/pubmed/22396538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334201
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