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The C Terminus of Mouse Monocyte Chemoattractant Protein 1 (MCP1) Mediates MCP1 Dimerization while Blocking Its Chemotactic Potency

The extracellular protease plasmin cleaves mouse MCP1 (monocyte chemoattractant protein 1) at lysine 104, releasing a 50-amino acid C-terminal domain. The cleavage event increases the chemotactic activity of MCP1 and, by doing so, promotes the progression of excitotoxic injury in the central nervous...

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Bibliographische Detailangaben
Hauptverfasser: Yao, Yao, Tsirka, Stella E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951225/
https://ncbi.nlm.nih.gov/pubmed/20682771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.124891
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