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Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood–brain barrier disruption

Previous studies have shown that plasmin cleaves monocyte chemoattractant protein 1 (MCP1; officially known as C-C motif chemokine 2, CCL2) at K104, and this cleavage enhances its chemotactic potency significantly. Accumulating evidence reveals that MCP1 also disrupts the integrity of the blood–brai...

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מידע ביבליוגרפי
Main Authors: Yao, Yao, Tsirka, Stella E.
פורמט: Artigo
שפה:Inglês
יצא לאור: Company of Biologists 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078815/
https://ncbi.nlm.nih.gov/pubmed/21486949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.082834
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