Design and Receptor Interactions of Obligate Dimeric Mutant of Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

Chemokine-receptor interactions regulate leukocyte trafficking during inflammation. CC chemokines exist in equilibrium between monomeric and dimeric forms. Although the monomers can activate chemokine receptors, dimerization is required for leukocyte recruitment in vivo, and it remains controversial...

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Detalhes bibliográficos
Main Authors: Tan, Joshua H. Y., Canals, Meritxell, Ludeman, Justin P., Wedderburn, Jamie, Boston, Christopher, Butler, Stephen J., Carrick, Ann Marie, Parody, Todd R., Taleski, Deni, Christopoulos, Arthur, Payne, Richard J., Stone, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340267/
https://ncbi.nlm.nih.gov/pubmed/22396538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334201
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