Dissociation of ATP-binding Cassette Nucleotide-binding Domain Dimers into Monomers during the Hydrolysis Cycle

ATP-binding cassette (ABC) proteins have two nucleotide-binding domains (NBDs) that work as dimers to bind and hydrolyze ATP, but the molecular mechanism of nucleotide hydrolysis is controversial. In particular, it is still unresolved whether hydrolysis leads to dissociation of the ATP-induced dimer...

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Hlavní autoři: Zoghbi, Maria E., Krishnan, Srinivasan, Altenberg, Guillermo A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340254/
https://ncbi.nlm.nih.gov/pubmed/22403405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340281
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