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Association/Dissociation of the Nucleotide-binding Domains of the ATP-binding Cassette Protein MsbA Measured during Continuous Hydrolysis

In ATP-binding cassette proteins, the two nucleotide-binding domains (NBDs) work as dimers to bind and hydrolyze ATP, but the molecular mechanism of nucleotide hydrolysis is controversial. It is still unresolved whether hydrolysis leads to dissociation of the ATP-induced dimers or partial opening of...

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書目詳細資料
Main Authors: Cooper, Rebecca S., Altenberg, Guillermo A.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774350/
https://ncbi.nlm.nih.gov/pubmed/23723071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.477976
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