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Association/Dissociation of the Nucleotide-binding Domains of the ATP-binding Cassette Protein MsbA Measured during Continuous Hydrolysis

In ATP-binding cassette proteins, the two nucleotide-binding domains (NBDs) work as dimers to bind and hydrolyze ATP, but the molecular mechanism of nucleotide hydrolysis is controversial. It is still unresolved whether hydrolysis leads to dissociation of the ATP-induced dimers or partial opening of...

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מידע ביבליוגרפי
Main Authors: Cooper, Rebecca S., Altenberg, Guillermo A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774350/
https://ncbi.nlm.nih.gov/pubmed/23723071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.477976
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