Time-resolved Fourier Transform Infrared Spectroscopy of the Nucleotide-binding Domain from the ATP-binding Cassette Transporter MsbA: ATP HYDROLYSIS IS THE RATE-LIMITING STEP IN THE CATALYTIC CYCLE

MsbA is an essential Escherichia coli ATP-binding cassette (ABC) transporter involved in the flipping of lipid A across the cytoplasmic membrane. It is a close homologue of human P-glycoprotein involved in multidrug resistance, and it similarly accepts a variety of small hydrophobic xenobiotics as t...

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Detalhes bibliográficos
Main Authors: Syberg, Falk, Suveyzdis, Yan, Kötting, Carsten, Gerwert, Klaus, Hofmann, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390668/
https://ncbi.nlm.nih.gov/pubmed/22593573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359208
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