Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication

We have discovered that 3,3′,5-triiodothyronine (T3) inhibits binding of a PIP-box sequence peptide to proliferating cell nuclear antigen (PCNA) protein by competing for the same binding site, as evidenced by the co-crystal structure of the PCNA-T3 complex at 2.1 Å resolution. Based on this observat...

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Bibliografiske detaljer
Main Authors: Punchihewa, Chandanamali, Inoue, Akira, Hishiki, Asami, Fujikawa, Yoshihiro, Connelly, Michele, Evison, Benjamin, Shao, Youming, Heath, Richard, Kuraoka, Isao, Rodrigues, Patrick, Hashimoto, Hiroshi, Kawanishi, Masanobu, Sato, Mamoru, Yagi, Takashi, Fujii, Naoaki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340206/
https://ncbi.nlm.nih.gov/pubmed/22383522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.353201
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