Calcium-Myristoyl Tug Is a New Mechanism for Intramolecular Tuning of Calcium Sensitivity and Target Enzyme Interaction for Guanylyl Cyclase-activating Protein 1: DYNAMIC CONNECTION BETWEEN N-FATTY ACYL GROUP AND EF-HAND CONTROLS CALCIUM SENSITIVITY

Guanylyl cyclase-activating protein 1 (GCAP1), a myristoylated Ca(2+) sensor in vision, regulates retinal guanylyl cyclase (RetGC). We show that protein-myristoyl group interactions control Ca(2+) sensitivity, apparent affinity for RetGC, and maximal level of cyclase activation. Mutating residues ne...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Peshenko, Igor V., Olshevskaya, Elena V., Lim, Sunghyuk, Ames, James B., Dizhoor, Alexander M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Neurobiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340203/
https://ncbi.nlm.nih.gov/pubmed/22383530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341883
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