Calcium-Myristoyl Tug Is a New Mechanism for Intramolecular Tuning of Calcium Sensitivity and Target Enzyme Interaction for Guanylyl Cyclase-activating Protein 1: DYNAMIC CONNECTION BETWEEN N-FATTY ACYL GROUP AND EF-HAND CONTROLS CALCIUM SENSITIVITY

Guanylyl cyclase-activating protein 1 (GCAP1), a myristoylated Ca(2+) sensor in vision, regulates retinal guanylyl cyclase (RetGC). We show that protein-myristoyl group interactions control Ca(2+) sensitivity, apparent affinity for RetGC, and maximal level of cyclase activation. Mutating residues ne...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Peshenko, Igor V., Olshevskaya, Elena V., Lim, Sunghyuk, Ames, James B., Dizhoor, Alexander M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340203/
https://ncbi.nlm.nih.gov/pubmed/22383530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341883
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados