ATP Binding Site Mutagenesis Reveals Different Subunit Stoichiometry of Functional P2X2/3 and P2X2/6 Receptors

The aim of the present experiments was to clarify the subunit stoichiometry of P2X2/3 and P2X2/6 receptors, where the same subunit (P2X2) forms a receptor with two different partners (P2X3 or P2X6). For this purpose, four non-functional Ala mutants of the P2X2, P2X3, and P2X6 subunits were generated...

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Detalhes bibliográficos
Main Authors: Hausmann, Ralf, Bodnar, Mandy, Woltersdorf, Ronja, Wang, Haihong, Fuchs, Martin, Messemer, Nanette, Qin, Ying, Günther, Janka, Riedel, Thomas, Grohmann, Marcus, Nieber, Karen, Schmalzing, Günther, Rubini, Patrizia, Illes, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340182/
https://ncbi.nlm.nih.gov/pubmed/22378790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.345207
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