Localization of the gate and selectivity filter of the full-length P2X7 receptor

The P2X7 receptor (P2X7R) belongs to the P2X family of ATP-gated cation channels. P2X7Rs are expressed in epithelial cells, leukocytes, and microglia, and they play important roles in immunological and inflammatory processes. P2X7Rs are obligate homotrimers, with each subunit having two transmembran...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Pippel, Anja, Stolz, Michaela, Woltersdorf, Ronja, Kless, Achim, Schmalzing, Günther, Markwardt, Fritz
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358401/
https://ncbi.nlm.nih.gov/pubmed/28235784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610414114
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