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Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening
BACKGROUND AND PURPOSE: It is assumed that ATP induces closure of the binding jaw of ligand-gated P2X receptors, which eventually results in the opening of the membrane channel and the flux of cations. Immobilization by cysteine mutagenesis of the binding jaw inhibited ATP-induced current responses,...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253458/ https://ncbi.nlm.nih.gov/pubmed/24989924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12830 |
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