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Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gating
P2X3 receptors (P2X3R) are trimeric ATP-gated cation channels involved in sensory neurotransmission and inflammatory pain. We used homology modeling and molecular dynamic simulations of the hP2X3R to identify inter-subunit interactions of residues that are instrumental to elucidate conformational ch...
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| Publicado no: | Purinergic Signal |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4854835/ https://ncbi.nlm.nih.gov/pubmed/26825305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-016-9496-5 |
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