Amino Acid Residues Constituting the Agonist Binding Site of the Human P2X3 Receptor

Homomeric P2X3 receptors are present in sensory ganglia and participate in pain perception. Amino acid (AA) residues were replaced in the four supposed nucleotide binding segments (NBSs) of the human (h) P2X3 receptor by alanine, and these mutants were expressed in HEK293 cells and Xenopus laevis oo...

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Bibliografiska uppgifter
Huvudupphovsmän: Bodnar, Mandy, Wang, Haihong, Riedel, Thomas, Hintze, Stefan, Kato, Erzsebet, Fallah, Ghada, Gröger-Arndt, Helke, Giniatullin, Rashid, Grohmann, Marcus, Hausmann, Ralf, Schmalzing, Günther, Illes, Peter, Rubini, Patrizia
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Neurobiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024770/
https://ncbi.nlm.nih.gov/pubmed/21098022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167437
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