Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II

During transcription, RNA polymerase II (RNAPII) must select the correct nucleotide, catalyze its addition to the growing RNA transcript, and move stepwise along the DNA until a gene is fully transcribed. In all kingdoms of life, transcription must be finely tuned to ensure an appropriate balance be...

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Detalles Bibliográficos
Main Authors: Larson, Matthew H., Zhou, Jing, Kaplan, Craig D., Palangat, Murali, Kornberg, Roger D., Landick, Robert, Block, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340090/
https://ncbi.nlm.nih.gov/pubmed/22493230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200939109
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