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Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting
The spindle checkpoint prevents aneuploidy by delaying anaphase onset until all sister chromatids achieve proper microtubule attachment. The kinetochore-bound checkpoint protein complex Mad1-Mad2 promotes the conformational activation of Mad2 and serves as a catalytic engine of checkpoint signaling....
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340083/ https://ncbi.nlm.nih.gov/pubmed/22493223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118210109 |
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