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Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition
Regulated conformational changes of proteins are critical for cellular signal transduction. The spindle checkpoint protein Mad2 is an unusual protein with two native folds: the latent open conformer (O-Mad2) and the activated closed conformer (C-Mad2). During mitosis, cytosolic O-Mad2 binds to the M...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993392/ https://ncbi.nlm.nih.gov/pubmed/21041666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009000107 |
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