Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint

The spindle checkpoint ensures accurate chromosome segregation by delaying anaphase in response to misaligned sister chromatids during mitosis. Upon checkpoint activation, Mad2 binds directly to Cdc20 and inhibits the anaphase-promoting complex or cyclosome (APC/C). Cdc20 binding triggers a dramatic...

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Bibliographic Details
Published in:EMBO J
Main Authors: Xia, Guohong, Luo, Xuelian, Habu, Toshiyuki, Rizo, Josep, Matsumoto, Tomohiro, Yu, Hongtao
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2004
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Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514937/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15257285/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600322
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