Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

In response to misaligned sister chromatids during mitosis, the spindle checkpoint protein Mad2 inhibits the anaphase-promoting complex or cyclosome (APC/C) through binding to its mitotic activator Cdc20, thus delaying anaphase onset. Mad1, an upstream regulator of Mad2, forms a tight core complex w...

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Bibliografiske detaljer
Main Authors: Yang, Maojun, Li, Bing, Liu, Chyong-Jy, Tomchick, Diana R, Machius, Mischa, Rizo, Josep, Yu, Hongtao, Luo, Xuelian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270309/
https://ncbi.nlm.nih.gov/pubmed/18318601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060050
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