Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

In response to misaligned sister chromatids during mitosis, the spindle checkpoint protein Mad2 inhibits the anaphase-promoting complex or cyclosome (APC/C) through binding to its mitotic activator Cdc20, thus delaying anaphase onset. Mad1, an upstream regulator of Mad2, forms a tight core complex w...

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Detaylı Bibliyografya
Asıl Yazarlar: Yang, Maojun, Li, Bing, Liu, Chyong-Jy, Tomchick, Diana R, Machius, Mischa, Rizo, Josep, Yu, Hongtao, Luo, Xuelian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2008
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270309/
https://ncbi.nlm.nih.gov/pubmed/18318601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060050
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